What is the difference between Chicago and Seattle. Some would say some hundred miles; others would say there’s huge difference between the two cities, but what I’ve learn through my travels is despite the differences, they are mostly the same. Sure Seattle has the Space Needle and Chicago is near the Great Lakes, but there is no real difference. They are both cities of temperamental weather (Fortunately, I didn’t get the worst of it.), they have some good people and some bad people, and from a distance, the cities even look the same, but then again, isn’t that so for most of other cities. I recommend you see for yourselves.